Anti-Ferritin Light Chain antibody (ab153976)

Overview

  • Product name
    Anti-Ferritin Light Chain antibody
    See all Ferritin Light Chain primary antibodies
  • Description
    Rabbit polyclonal to Ferritin Light Chain
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rabbit, Cat, Dog
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-175 of Human Ferritin Light Chain (UniProt ID: P02792).

  • Positive control
    • 293T, HepG2 and NIH3T3 whole cell lysates; Human A549 xenograft tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab153976 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 20 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
  • Involvement in disease
    Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.
    Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
  • Sequence similarities
    Belongs to the ferritin family.
    Contains 1 ferritin-like diiron domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ferritin L chain antibody
    • Ferritin L subunit antibody
    • Ferritin light chain antibody
    • Ferritin light polypeptide antibody
    • ferritin light polypeptide like 3 antibody
    • FRIL_HUMAN antibody
    • FTL antibody
    • LFTD antibody
    • NBIA 3 antibody
    • NBIA3 antibody
    see all

Images

  • Anti-Ferritin Light Chain antibody (ab153976) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 20 kDa
  • Anti-Ferritin Light Chain antibody (ab153976) at 1/1000 dilution + NIH3T3 whole cell lysate at 30 µg

    Predicted band size : 20 kDa
  • Immunohistochemical analysis of paraffin-embedded Human A549 xenograft tissue labeling Ferritin Light Chain with ab153976 at 1/500 dilution.

References

ab153976 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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