Application notesIs unsuitable for Flow Cyt or IHC-P.
FunctionStores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
Involvement in diseaseDefects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
Sequence similaritiesBelongs to the ferritin family. Contains 1 ferritin-like diiron domain.
Western blot - Ferritin Light Chain antibody [EPR5259] (ab109019)
All lanes : Anti-Ferritin Light Chain antibody [EPR5259] (ab109019) at 1/1000 dilution
Lane 1 : Human fetal liver lysate Lane 2 : HepG2 cell lysate Lane 3 : HeLa cells lysate
Lysates/proteins at 10 µg per lane.
Predicted band size : 20 kDa
References for Anti-Ferritin Light Chain antibody [EPR5259] (ab109019)
This product has been referenced in:
Wu T et al. Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway. PLoS One11:e0149361 (2016).
WB, IHC, ICC/IF
Read more (PubMed: 26871431) »