Overview

  • Product name
    Ferrostatin 1
  • Description
    Potent, selective erastin-induced ferroptosis inhibitor
  • Biological description
    Potent, selective erastin-induced ferroptosis inhibitor (EC50 = 60 nM). Selectively inhibits Ras selective lethal compound-induced death. Blocks Artesunate (ab142829)-induced lipid peroxidation and cell death. Has no effect on CYP2E1 expression or cellular GSH level.

Properties

  • Molecular weight
    262.35
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C15H22N2O2
  • CAS Number
    347174-05-4
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    O=C(OCC)c2ccc(NC1CCCCC1)c(N)c2
  • Source

    Synthetic

References

This product has been referenced in:
  • Lorincz T  et al. Ferroptosis is Involved in Acetaminophen Induced Cell Death. Pathol Oncol Res 21:1115-21 (2015). Read more (PubMed: 25962350) »
  • Eling N  et al. Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience 2:517-32 (2015). Read more (PubMed: 26097885) »
  • Liu Y  et al. The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis. Biol Pharm Bull 38:1234-9 (2015). Read more (PubMed: 26235588) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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