Overview

  • Product nameFFN511
  • Description
    First novel fluorescent false neurotransmitter. Enables optical imaging of presynaptic terminal activity.
  • Alternative names
    • Fluorescent False Neurotransmitter 511
  • Biological descriptionFirst novel fluorescent false neurotransmitter. Enables optical imaging of presynaptic terminal activity.
    Inhibits 5-HT binding to VMAT2 (IC50 = 1 µM (comparable to dopamine itself)). Released via exocytosis in the striatum in mouse acute slice preparation. Labels dopamine and other presynaptic terminals in the striatum.
    Compatible with GFP tags and other optical probes. Sufficiently bright, photostable and suitable for two-photon fluorescence microscopy.
    View the technique online

    For highly selective labelling of dopaminergic presynaptic termainals FFN102 (ab120866) is recommended.
  • Purity> 99%

Properties

    References for FFN511 (ab120331)

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    The information we have in relation to the emission and excitation of FFN511 is from the following reference:

    Gubernator NG et al. Fluorescent false neurotransmitters vi...

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    We do ot have any information about the pKa value of FFN511. The available literature also does not seem to mention the pKa value of FFN511.

    In relation to the pH range, the only mention is in the supplem...

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    As we do not currently undertake our own research I can offer you advice based on information available in a recent paper by Gubernator et al., 2009. I can confirm that excitation of FFN551 occurs at 760 nm, with optimal fluorescence of striatal termin...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"