Overview

  • Product name
  • Description
    Rabbit polyclonal to FGF10
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to a sequence at the N-terminal of Human FGF10.

  • Positive control
    • U87, HeLa, A549, 293T and MCF7 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab115825 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 23 kDa.

Target

  • Function
    Could be a growth factor active in the process of wound healing. Acts as a mitogen in the lung. May act in a manner similar to FGF-7.
  • Involvement in disease
    Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
    Defects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.
  • Sequence similarities
    Belongs to the heparin-binding growth factors family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • BB213776 antibody
    • fd11d03 antibody
    • FGF 10 antibody
    • FGF-10 antibody
    • FGF10 antibody
    • FGF10_HUMAN antibody
    • Fibroblast growth factor 10 antibody
    • Keratinocyte growth factor 2 antibody
    • KGF 2 antibody
    • Produced by fibroblasts of urinary bladder lamina propria antibody
    • wu:fd11d03 antibody
    • zgc:109774 antibody
    see all

Anti-FGF10 antibody images

  • All lanes : Anti-FGF10 antibody (ab115825) at 1 µg/ml

    Lane 1 : U87 whole cell lysate
    Lane 2 : HeLa whole cell lysate
    Lane 3 : A549 whole cell lysate
    Lane 4 : 293T whole cell lysate
    Lane 5 : MCF7 whole cell lysate


    Predicted band size : 23 kDa

References for Anti-FGF10 antibody (ab115825)

This product has been referenced in:
  • Li YH  et al. Neuron-derived FGF10 ameliorates cerebral ischemia injury via inhibiting NF-?B-dependent neuroinflammation and activating PI3K/Akt survival signaling pathway in mice. Sci Rep 6:19869 (2016). Mouse . Read more (PubMed: 26813160) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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