Overview

  • Product nameAnti-FGF10 antibody - C-terminal
    See all FGF10 primary antibodies
  • Description
    Rabbit polyclonal to FGF10 - C-terminal
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the C terminal region of Human FGF10.

  • Positive control
    • Human prostate carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab80064 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/10 - 1/50.

Target

  • FunctionCould be a growth factor active in the process of wound healing. Acts as a mitogen in the lung. May act in a manner similar to FGF-7.
  • Involvement in diseaseDefects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
    Defects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.
  • Sequence similaritiesBelongs to the heparin-binding growth factors family.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • BB213776 antibody
    • fd11d03 antibody
    • FGF 10 antibody
    • FGF-10 antibody
    • FGF10 antibody
    • FGF10_HUMAN antibody
    • Fibroblast growth factor 10 antibody
    • Keratinocyte growth factor 2 antibody
    • KGF 2 antibody
    • Produced by fibroblasts of urinary bladder lamina propria antibody
    • wu:fd11d03 antibody
    • zgc:109774 antibody
    see all

Anti-FGF10 antibody - C-terminal images

  • Immunohistochemistry analysis of FGF10 in formalin-fixed, paraffin-embedded human prostate carcinoma tissue using ab80064 at 1/10 dilution, followed by a peroxidase-conjugated secondary antibody and DAB staining.

References for Anti-FGF10 antibody - C-terminal (ab80064)

ab80064 has not yet been referenced specifically in any publications.

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