Overview

  • Product nameAnti-FGF2 antibody [0.T.50]
    See all FGF2 primary antibodies
  • Description
    Mouse monoclonal [0.T.50] to FGF2
  • Specificityab33103 recognizes the native, non denatured form of basic FGF. It does not recognise acidic FGF (HBGF 1).
  • Tested applicationsSuitable for: Neutralisingmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Mouse, Rat, Cow, Human
  • Immunogen

    Full length native protein: Purified bovine brain basic FGF (HBGF-2).

Properties

Applications

Our Abpromise guarantee covers the use of ab33103 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Neutralising Use a concentration of 2.5 µg/ml.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionPlays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis (PubMed:23469107).
    • Tissue specificityExpressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.
    • Sequence similaritiesBelongs to the heparin-binding growth factors family.
    • Post-translational
      modifications
      Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
      Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.
    • Cellular localizationSecreted. Nucleus. Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.
    • Information by UniProt
    • Database links
    • Alternative names
      • Basic fibroblast growth factor antibody
      • Basic fibroblast growth factor bFGF antibody
      • BFGF antibody
      • FGF 2 antibody
      • FGF B antibody
      • FGF-2 antibody
      • Fgf2 antibody
      • FGF2 basic antibody
      • FGF2_HUMAN antibody
      • FGFB antibody
      • Fibroblast growth factor 2 (basic) antibody
      • Fibroblast growth factor 2 antibody
      • Fibroblast growth factor, basic antibody
      • HBGF 2 antibody
      • HBGF-2 antibody
      • HBGF2 antibody
      • HBGH 2 antibody
      • HBGH2 antibody
      • Heparin binding growth factor 2 precursor antibody
      • Heparin-binding growth factor 2 antibody
      • Prostatropin antibody
      see all

    References for Anti-FGF2 antibody [0.T.50] (ab33103)

    This product has been referenced in:
    • Kujawski M  et al. Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice. J Clin Invest 118:3367-77 (2008). Neutralising ; Human . Read more (PubMed: 18776941) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"