Overview

  • Product name
  • Description
    Goat polyclonal to FGF8
  • Specificity
    ab181492 is expected to recognize all reported isoforms (NP_149355.1; NP_006110.1; NP_149354.1; NP_149353.1).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to Human FGF8 aa 201-215 (Cysteine residue). NP_149355.1
    Sequence:

    HTTEQSLRFEFLNYP


    Database link: P55075

  • Positive control
    • Jurkat cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab181492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 27 kDa).

Target

  • Function
    Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells.
  • Involvement in disease
    Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6) [MIM:612702]. Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
    Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
  • Sequence similarities
    Belongs to the heparin-binding growth factors family.
  • Developmental stage
    In adults expression is restricted to the gonads.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • AIGF antibody
    • Androgen induced growth factor antibody
    • Androgen-induced growth factor antibody
    • FGF 8 antibody
    • FGF-8 antibody
    • FGF-8b antibody
    • FGF8 antibody
    • FGF8_HUMAN antibody
    • Fibroblast growth factor 8 (androgen induced) antibody
    • Fibroblast growth factor 8 antibody
    • Fibroblast growth factor 8 precursor antibody
    • HBGF 8 antibody
    • HBGF-8 antibody
    • HBGF8 antibody
    • Heparin-binding growth factor 8 antibody
    • HH6 antibody
    • KAL6 antibody
    see all

Images

  • Anti-FGF8 antibody (ab181492) at 3 µg/ml + Jurkat cell lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 27 kDa

    Primary incubation was 1 hour.

References

This product has been referenced in:
  • Gao Q  et al. The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Nat Commun 8:15279 (2017). Read more (PubMed: 28589943) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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