Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab54756 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionStimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells.
    • Involvement in diseaseDefects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6) [MIM:612702]. Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
      Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
    • Sequence similaritiesBelongs to the heparin-binding growth factors family.
    • Developmental stageIn adults expression is restricted to the gonads.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • AIGF antibody
      • Androgen induced growth factor antibody
      • Androgen-induced growth factor antibody
      • FGF 8 antibody
      • FGF-8 antibody
      • FGF8 antibody
      • FGF8_HUMAN antibody
      • Fibroblast growth factor 8 (androgen induced) antibody
      • Fibroblast growth factor 8 antibody
      • Fibroblast growth factor 8 precursor antibody
      • HBGF 8 antibody
      • HBGF-8 antibody
      • HBGF8 antibody
      • Heparin-binding growth factor 8 antibody
      • HH6 antibody
      • KAL6 antibody
      see all

    Anti-FGF8 antibody images



    • Predicted band size : 27 kDa
      FGF8 antibody (ab54756) at 1ug/lane + HepG2 cell lysate at 25ug/lane.

    References for Anti-FGF8 antibody (ab54756)

    ab54756 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"