Overview

  • Product nameAnti-FGFR1 alpha antibody [M1C4]
    See all FGFR1 alpha primary antibodies
  • Description
    Mouse monoclonal [M1C4] to FGFR1 alpha
  • SpecificityReacts with alpha isoform of FRFR1.
  • Tested applicationsSuitable for: IP, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant human ectodomain of FGFr1a expressed in E. coli beginning with pro23; antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences.

  • EpitopeCOOH-terminus of unique NH2-terminal Ig loop of FGFr1. Epitope is within the sequence between glu75 and ser119 of FGFr1a. Epitope is masked in undenatured FGFr1a.

Properties

Applications

Our Abpromise guarantee covers the use of ab830 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP
WB
  • Application notesWestern blotting: at 1 ug/ml recognizes 10 ng recombinant bacterial, baculo-viral, or native FGFr1.
    Immunoprecipitation: Ig loop I fragment of denatured, intact FGFr1a.
    Immunohistochemistry: untested; predicted to be poor due to masked epitope.
  • Target

    • RelevanceFGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family and contains an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is widely expressed, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM.
    • Cellular localizationCell Membrane
    • Database links
    • Alternative names
      • BFGFR antibody
      • CD331 antibody
      • CEK antibody
      • FGFBR antibody
      • FGFR1 antibody
      • FLG antibody
      • FLT2 antibody
      • FMS like tyrosine kinase 2 antibody
      • HBGFR antibody
      • KAL2 antibody
      • N SAM antibody
      • OGD antibody
      see all

    References for Anti-FGFR1 alpha antibody [M1C4] (ab830)

    ab830 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"