Mouse Predicted to work with:
Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Human, Pig, Zebrafish
Synthetic peptide corresponding to a region within N terminal amino acids 128-177 (NETKHRVLQY VGGVMSVEMQ APKLLWLKEN LREICWDKAG HFFDLPDFLS) of Mouse FGGY carbohydrate kinase domain containing, isoform 2 (NP_083623).
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
Tissue specificityExpressed in kidney, lung and small intestine and to a lower extent in liver and detected in cerebrospinal fluid (at protein level).
Involvement in diseaseDefects in FGGY are associated with sporadic amyotrophic lateral sclerosis (ALS) [MIM:105400]. Amyotrophic lateral sclerosis is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors.
Sequence similaritiesBelongs to the FGGY kinase family.
Developmental stageExpressed in fetal brain (at protein level).