Overview

  • Product nameAnti-FH antibody
    See all FH primary antibodies
  • Description
    Goat polyclonal to FH
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Horse, Chicken, Cow, Dog, Pig, Zebrafish, Chinese Hamster
  • Immunogen

    Synthetic peptide:

    C-HPNDHVNKSQSSND

    corresponding to internal sequence amino acids 176-189 of Human FH

  • Positive control
    • Human Heart and Human Skeletal Muscle tissue Human Kidney lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab113963 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.01 µg/ml. Predicted molecular weight: 55 kDa.
ELISA 1/64000.
IHC-P Use a concentration of 3.75 µg/ml.

Target

  • FunctionAlso acts as a tumor suppressor.
  • PathwayCarbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.
  • Involvement in diseaseDefects in FH are the cause of fumarase deficiency (FHD) [MIM:606812]; also known as fumaricaciduria. FHD is characterized by progressive encephalopathy, developmental delay, hypotonia, cerebral atrophy and lactic and pyruvic acidemia.
    Defects in FH are the cause of multiple cutaneous and uterine leiomyomata (MCUL1) [MIM:150800]. MCUL1 is an autosomal dominant condition in which affected individuals develop benign smooth muscle tumors (leiomyomata) of the skin. Affected females also usually develop leiomyomata of the uterus (fibroids).
    Defects in FH are the cause of hereditary leiomyomatosis and renal cell cancer (HLRCC) [MIM:605839].
  • Sequence similaritiesBelongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  • Cellular localizationCytoplasm and Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • FH antibody
    • Fumarase antibody
    • Fumarate hydratase antibody
    • Fumarate hydratase mitochondrial antibody
    • Fumarate hydratase, mitochondrial antibody
    • FUMH_HUMAN antibody
    • HLRCC antibody
    • LRCC antibody
    • MCL antibody
    • MCUL 1 antibody
    • MCUL1 antibody
    • MS709 antibody
    • Multiple hereditary cutaneous leiomyomata antibody
    see all

Anti-FH antibody images

  • Immunohistochemical staining of Human Heart using ab113963 at 3.75µg/ml
  • Immunohistochemical staining of Human Skeletal Muscle using ab113963 at 3.75µg/ml
  • Anti-FH antibody (ab113963) at 0.01 µg/ml + Human Kidney lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 55 kDa

References for Anti-FH antibody (ab113963)

This product has been referenced in:
  • Zecchini V  et al. Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer. EMBO J 33:1365-82 (2014). WB, ICC/IF . Read more (PubMed: 24837709) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"