• Product nameAnti-FH antibody
    See all FH primary antibodies
  • Description
    Mouse monoclonal to FH
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 33-511 of Human FH



Our Abpromise guarantee covers the use of ab58232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 55 kDa.
ICC/IF Use at an assay dependent concentration. PubMed: 22867999


  • FunctionAlso acts as a tumor suppressor.
  • PathwayCarbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.
  • Involvement in diseaseDefects in FH are the cause of fumarase deficiency (FHD) [MIM:606812]; also known as fumaricaciduria. FHD is characterized by progressive encephalopathy, developmental delay, hypotonia, cerebral atrophy and lactic and pyruvic acidemia.
    Defects in FH are the cause of multiple cutaneous and uterine leiomyomata (MCUL1) [MIM:150800]. MCUL1 is an autosomal dominant condition in which affected individuals develop benign smooth muscle tumors (leiomyomata) of the skin. Affected females also usually develop leiomyomata of the uterus (fibroids).
    Defects in FH are the cause of hereditary leiomyomatosis and renal cell cancer (HLRCC) [MIM:605839].
  • Sequence similaritiesBelongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  • Cellular localizationCytoplasm and Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • FH antibody
    • Fumarase antibody
    • Fumarate hydratase antibody
    • Fumarate hydratase mitochondrial antibody
    • Fumarate hydratase, mitochondrial antibody
    • FUMH_HUMAN antibody
    • HLRCC antibody
    • LRCC antibody
    • MCL antibody
    • MCUL 1 antibody
    • MCUL1 antibody
    • MS709 antibody
    • Multiple hereditary cutaneous leiomyomata antibody
    see all

Anti-FH antibody images

  • Predicted band size : 55 kDa
    FH antibody (ab58232) at 1ug/lane + HeLa cell lysate at 25ug/lane.
  • Immunofluorescence analysis of UOK268 cells, staining FH with ab58232.

    Cells were fixed in formaldehyde and permeabilized with 0.2% Triton X-100. Samples were incubated with primary antibody (1/200) for 1 hour at room temperature. An AlexaFluor®488-conjugated goat anti-mouse IgG (1/500) was used as the secondary antibody.

References for Anti-FH antibody (ab58232)

This product has been referenced in:
  • Beernink PT  et al. Heterogeneity in rhesus macaque complement factor H binding to meningococcal factor H binding protein (FHbp) informs selection of primates to assess immunogenicity of FHbp-based vaccines. Clin Vaccine Immunol 21:1505-11 (2014). Read more (PubMed: 25185576) »
  • Yang Y  et al. A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer. Cancer Genet 205:377-90 (2012). ICC/IF ; Human . Read more (PubMed: 22867999) »

See all 4 Publications for this product

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