Anti-Fibrinogen gamma chain antibody (ab86579)


  • Product nameAnti-Fibrinogen gamma chain antibody
    See all Fibrinogen gamma chain primary antibodies
  • Description
    Rabbit polyclonal to Fibrinogen gamma chain
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (Human) from the C terminus conjugated to KLH.

  • Positive control
    • NCI-H460 cell line lysate


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityAmmonium Sulphate Precipitation
  • Purification notesThis antibody is prepared by Saturated Ammonium Sulfate precipitation followed by dialysis against PBS.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab86579 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Predicted molecular weight: 52 kDa.
ELISA 1/1000.


  • FunctionFibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
  • Involvement in diseaseDefects in FGG are a cause of thrombophilia.
    Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen.
  • Sequence similaritiesContains 1 fibrinogen C-terminal domain.
  • DomainA long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
  • Post-translational
    Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
    Sulfation of C-terminal tyrosines increases affinity for thrombin.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • FGG antibody
    • FIBG_HUMAN antibody
    • Fibrinogen gamma chain antibody
    • Fibrinogen gamma polypeptide antibody
    • fibrinogen gamma-b chain antibody
    see all

Anti-Fibrinogen gamma chain antibody images

  • Anti-Fibrinogen gamma chain antibody (ab86579) at 1/50 dilution + NCI-H460 cell line lysate at 35 µg

    Predicted band size : 52 kDa
    Observed band size : 52 kDa
    Additional bands at : 36 kDa,70 kDa. We are unsure as to the identity of these extra bands.

References for Anti-Fibrinogen gamma chain antibody (ab86579)

ab86579 has not yet been referenced specifically in any publications.

Product Wall

ab86579 was generated using a synthetic peptide on the C-terminus of the protein. So, for detection methods like Western blot or IHC, the target protein are denatured. Conformational changes would not matter. If you are going to use it to detect native...

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