Anti-Fibrinogen gamma chain antibody [EPR3084] (ab92481)


  • Product nameAnti-Fibrinogen gamma chain antibody [EPR3084]
    See all Fibrinogen gamma chain primary antibodies
  • Description
    Rabbit monoclonal [EPR3084] to Fibrinogen gamma chain
  • Tested applicationsSuitable for: WB, IHC-Pmore details
    Unsuitable for: Flow Cyt or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to residues in Human Fibrinogen gamma chain (UniProt ID: P02679).

  • Positive control
    • WB: Human plasma lysate IHC-P: Human liver tissue
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab92481 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-P: 1/100 - 1/250. Heat mediated antigen retrieval is recommended before commencing with IHC staining protocol. HRP/AP polymerized antibody is recommended for use as a secondary antibody.
    WB: 1/500 - 1/1000. Predicted molecular weight: 52 kDa.

    Is unsuitable for Flow Cyt or IP.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionFibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
    • Involvement in diseaseDefects in FGG are a cause of thrombophilia.
      Defects in FGG are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen.
    • Sequence similaritiesContains 1 fibrinogen C-terminal domain.
    • DomainA long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
    • Post-translational
      Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
      Sulfation of C-terminal tyrosines increases affinity for thrombin.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • FGG antibody
      • FIBG_HUMAN antibody
      • Fibrinogen gamma chain antibody
      • Fibrinogen gamma polypeptide antibody
      • fibrinogen gamma-b chain antibody
      see all

    Anti-Fibrinogen gamma chain antibody [EPR3084] images

    • Anti-Fibrinogen gamma chain antibody [EPR3084] (ab92481) at 1/500 dilution + Human plasma lysate at 10 µg

      HRP labelled goat anti-rabbit IgG at 1/2000 dilution

      Predicted band size : 52 kDa
    • ab92481, at a 1/100 dilution, staining Fibrinogen gamma chain in paraffin embedded Human liver tissue by Immunohistochemistry.

    References for Anti-Fibrinogen gamma chain antibody [EPR3084] (ab92481)

    ab92481 has not yet been referenced specifically in any publications.

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    Thank you for your phone call. I am still waiting for information regarding the immunogens for ab92481 and ab92510, but I will let you know as soon as I have any additional information.


    Expiration date: August 16t...

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