Anti-Fibrinopeptide B antibody (Biotin) (ab48257)

Overview

  • Product nameAnti-Fibrinopeptide B antibody (Biotin)
    See all Fibrinopeptide B primary antibodies
  • Description
    Rabbit polyclonal to Fibrinopeptide B (Biotin)
  • ConjugationBiotin
  • Tested applicationsSuitable for: ELISA, IP, RIAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    QGVNDNEEGFFSAR

    conjugated to KLH via carboxyl group, corresponding to amino acids 31-44 of Human Fibrinopeptide B.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 50% Glycerol, PBS, pH 7.5
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab48257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
IP Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.

Target

  • FunctionFibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
  • Involvement in diseaseDefects in FGB are a cause of thrombophilia.
    Defects in FGB are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen.
  • Sequence similaritiesContains 1 fibrinogen C-terminal domain.
  • DomainA long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
  • Post-translational
    modifications
    Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Epididymis secretory sperm binding protein Li 78p antibody
    • FGB antibody
    • FIBB_HUMAN antibody
    • Fibrinogen B beta polypeptide antibody
    • Fibrinogen beta chain antibody
    • Fibrinogen beta polypeptide chain antibody
    • Fibrinopeptide B antibody
    • HEL S 78p antibody
    • Liver regeneration-related protein LRRG036/LRRG043/LRRG189 antibody
    • MGC104327 antibody
    • MGC120405 antibody
    • OTTHUMP00000197066 antibody
    see all

References for Anti-Fibrinopeptide B antibody (Biotin) (ab48257)

ab48257 has not yet been referenced specifically in any publications.

Product Wall

We have added the unconjugated version of ab48257 to the catalog as ab198560 (link below):



http://www.abcam.com/fibrinopeptide-b-antibody-ab198560.html

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"