Overview

  • Product nameAnti-Fibulin 5 antibody
    See all Fibulin 5 primary antibodies
  • Description
    Goat polyclonal to Fibulin 5
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide:

    C-RPIKGPREIQLDLE

    , corresponding to internal sequence amino acids 408-421 of Human Fibulin 5

  • Positive control
    • Human Colon, Heart or Ovary lysates.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab53515 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesPeptide ELISA: antibody detection limit dilution 1:32,000.

    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 50 kDa, and an additional band, of unknown identity, at 23 kDa (predicted molecular weight: 50 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPromotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling.
    • Tissue specificityExpressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes.
    • Involvement in diseaseDefects in FBLN5 are a cause of autosomal dominant cutis laxa (ADCL) [MIM:123700]. Hereditary cutis laxa refers to a heterogeneous group of connective tissue disorders characterized by cutaneous abnormalities and variable systemic manifestations. The most constant clinical feature is loose skin, sagging over the face and trunk. Hereditary cutis laxa is inherited in both autosomal dominant and autosomal recessive modes. Autosomal dominant cutis laxa is a relatively benign inherited and acquired connective tissue disorder.
      Defects in FBLN5 are a cause of cutis laxa autosomal recessive type 1 (ARCL1) [MIM:219100]. Hereditary cutis laxa refers to a heterogeneous group of connective tissue disorders characterized by cutaneous abnormalities and variable systemic manifestations. The most constant clinical feature is loose skin, sagging over the face and trunk. Hereditary cutis laxa is inherited in both autosomal dominant and autosomal recessive modes. ARCL1 shows the most severe phenotype and has the poorest prognosis. In addition to the skin, internal organs enriched in elastic fibers, such as the lung and arteries, are affected.
      Defects in FBLN5 are the cause of age-related macular degeneration type 3 (ARMD3) [MIM:608895]. ARMD is a multifactorial disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
    • Sequence similaritiesBelongs to the fibulin family.
      Contains 6 EGF-like domains.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • ADCL2 antibody
      • ARCL1A antibody
      • ARMD3 antibody
      • Dance antibody
      • Developmental arteries and neural crest EGF like protein antibody
      • Developmental arteries and neural crest EGF-like protein antibody
      • EVEC antibody
      • Fbln5 antibody
      • FBLN5_HUMAN antibody
      • FIBL 5 antibody
      • FIBL-5 antibody
      • Fibulin-5 antibody
      • FLJ90059 antibody
      • UP50 antibody
      • Urine p50 protein antibody
      see all

    Anti-Fibulin 5 antibody images

    • Anti-Fibulin 5 antibody (ab53515) at 0.1 µg/ml + Human Ovary lysate (35µg protein in RIPA buffer).

      Predicted band size : 50 kDa
      Observed band size : 50 kDa
      Additional bands at : 23 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-Fibulin 5 antibody (ab53515)

    ab53515 has not yet been referenced specifically in any publications.

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