Overview

  • Product name
  • Description
    Rabbit polyclonal to FIP1L1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Horse, Cow, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to a region within amino acids 544 - 594 of Human FIP1L1 (NP_112179.2)

  • Positive control
    • Anaplastic thyroid carcinoma, bladder cell carcinoma, breast carcinoma, colon carcinoma, Hodgkin's lymphoma, linitis plastica stomach cancer, lung adenocarcinoma, ovarian carcinoma, pancreatic islet cell tumor, prostate carcinoma, skin basal cell carcinoma, skin squamous cell carcinoma, small cell lung Cancer, stomach adenocarcinoma, skin cancer.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab84670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer may enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      FIP1L1 is an integral subunit of the cleavage and polyadenylation specificity factor (CPSF) complex. CPSF is a multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA and interacts with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 binds to U-rich RNA sequence elements surrounding the poly(A) site and contributes to poly(A) site recognition and stimulates poly(A) addition. FIP1L1 may act to tether poly(A) polymerase to the CPSF complex. A fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA) is a recurrent molecular lesion in eosinophilia-associated myeloproliferative disorders.
    • Cellular localization
      Nuclear
    • Database links
    • Alternative names
      • DKFZp586K0717 antibody
      • Factor interacting with PAP antibody
      • FIP1 antibody
      • FIP1 like 1 (S cerevisiae) antibody
      • FIP1 like 1 antibody
      • FLJ33619 antibody
      • hFip 1 antibody
      • hFip1 antibody
      • Pre mRNA 3 end processing factor FIP1 antibody
      • Rearranged in hypereosinophilia antibody
      • RHE antibody
      see all

    Images

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human pancreatic islet cell tumor, using 1/100 ab84670 followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human skin cancer, using 1/100 ab84670 followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Humanbreast carcinoma, using 1/100 ab84670 in conjunction with 1/100 Goat anti-Rabbit IgG conjugated with a fluorescent dye (red).

    References

    ab84670 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab84670.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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