Overview

  • Product name
  • Description
    Rabbit polyclonal to FKBP135
  • Specificity
    We have data to indicate that this antibody may not cross react with Mouse. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.
  • Tested applications
    Suitable for: IPmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide (Unfortunately the amino acid sequence is considered to be commercially sensitive). The peptide sequence is within the region between aa1175 and the C-terminus (aa1234) of human FKBP135 using the numbering given in TrEMBL entry Q9Y4D0 (GeneID 23307).

  • Positive control
    • HeLa cells.
  • General notes
    Centrifuge tube to remove product from lid.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.1% Sodium Azide
    Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Antibody was purified using an epitope specific to FKBP135 immobilized on solid support.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab14434 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP
  • Application notes
    IP: Use at a concentration of 1 - 4 mcg/ml.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.
    • Sequence similarities
      Belongs to the FKBP-type PPIase family.
      Contains 1 PPIase FKBP-type domain.
    • Domain
      The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity.
      The central coiled-coil region is responsible for association with early endosomes.
    • Cellular localization
      Cytoplasm. Cell projection > axon. Early endosome. Present in axons and neuronal growth cones.
    • Information by UniProt
    • Database links
    • Alternative names
      • 133 kDa FK506-binding protein antibody
      • 133 kDa FKBP antibody
      • C430014M02Rik antibody
      • FK506 binding protein 135 antibody
      • FK506-binding protein 15 antibody
      • FKB15_HUMAN antibody
      • FKBO133 antibody
      • FKBP-133 antibody
      • FKBP-15 antibody
      • FKBP133 antibody
      • Fkbp15 antibody
      • KIAA0674 antibody
      • mKIAA0674 antibody
      • Peptidyl prolyl cis trans isomerase antibody
      • RIKEN cDNA C430014M02 gene antibody
      • RP23 64F17.7 antibody
      • WAFL antibody
      • WASP and FKBP-like antibody
      see all

    Anti-FKBP135 antibody images

    • Antibodies: ab14432ab14433 and ab14434 used at 2 mcg/mg extract for IP. FKBP135 in NE and immunoprecipitated FKBP135 were detected using ab14434 at 0.2 mcg/ml. Detection: Chemiluminescence with an exposure time of 10 minutes.

    References for Anti-FKBP135 antibody (ab14434)

    ab14434 has not yet been referenced specifically in any publications.

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    I am sorry if it was misleading but the image supplied with Anti-FKBP135 antibodies ab14432, ab14433 and ab14434 are the same. They illustrate the IP performed with ab14432,...

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