Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab51928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-FKBP38 antibody (ab24450)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • 38 kDa FK506-binding protein
    • 38 kDa FKBP
    • 38kDa
    • FK506 binding protein 8
    • FK506 binding protein 8, 38kDa
    • FK506 binding protein, 38kDa
    • FK506-binding protein 8
    • FKBP 38
    • FKBP-38
    • FKBP-8
    • Fkbp8
    • FKBP8_HUMAN
    • FKBPR38
    • hFKBP38
    • Peptidyl-prolyl cis-trans isomerase FKBP8
    • PPIase FKBP8
    • Rotamase
    • Sam11
    see all
  • FunctionConstitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
  • Tissue specificityWidely expressed. Highest levels seen in the brain.
  • Sequence similaritiesContains 1 PPIase FKBP-type domain.
    Contains 3 TPR repeats.
  • Cellular localizationMitochondrion membrane.
  • Information by UniProt

References for FKBP38 peptide (ab51928)

ab51928 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab51928.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"