Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab51928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-FKBP38 antibody (ab24450)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • 38 kDa FK506-binding protein
    • 38 kDa FKBP
    • 38kDa
    • FK506 binding protein 8
    • FK506 binding protein 8, 38kDa
    • FK506 binding protein, 38kDa
    • FK506-binding protein 8
    • FKBP 38
    • FKBP-38
    • FKBP-8
    • Fkbp8
    • FKBP8_HUMAN
    • FKBPR38
    • hFKBP38
    • Peptidyl-prolyl cis-trans isomerase FKBP8
    • PPIase FKBP8
    • Rotamase
    • Sam11
    see all
  • Function
    Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
  • Tissue specificity
    Widely expressed. Highest levels seen in the brain.
  • Sequence similarities
    Contains 1 PPIase FKBP-type domain.
    Contains 3 TPR repeats.
  • Cellular localization
    Mitochondrion membrane.
  • Information by UniProt

References

ab51928 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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