Overview

  • Product nameAnti-FKBP51 antibody
    See all FKBP51 primary antibodies
  • Description
    Rabbit polyclonal to FKBP51
  • Tested applicationsSuitable for: WB, IP, ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Hamster, Dog, Human, Xenopus laevis, Non Human Primates
  • Immunogen

    Synthetic peptide corresponding to Human FKBP51 aa 394-407.
    Sequence:

    CQKKAKEHNERDRR


    (Peptide available as ab4924)

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab2901 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 51 kDa.Can be blocked with FKBP51 peptide (ab4924). By Western blot, this antibody detects an ~51 kDa protein representing FKBP 51 in HeLa cell lysate. By Western blot this antibody also detects FKBP 51 in whole tissue extracts from rat kidney and rat and mouse testes.
IP Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration. PubMed: 20422297

Target

  • FunctionInteracts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
  • Tissue specificityWidely expressed, enriched in testis compared to other tissues.
  • Sequence similaritiesContains 2 PPIase FKBP-type domains.
    Contains 3 TPR repeats.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 51 kDa FK506 binding protein 5 antibody
    • 51 kDa FK506 binding protein antibody
    • 51 kDa FK506-binding protein antibody
    • 51 kDa FKBP antibody
    • 54 kDa progesterone receptor associated immunophilin antibody
    • 54 kDa progesterone receptor-associated immunophilin antibody
    • AIG 6 antibody
    • AIG6 antibody
    • Androgen regulated protein 6 antibody
    • Androgen-regulated protein 6 antibody
    • FF1 antigen antibody
    • FK506 binding protein 5 antibody
    • FK506-binding protein 5 antibody
    • FKBP 5 antibody
    • FKBP 51 antibody
    • FKBP 54 antibody
    • FKBP-5 antibody
    • FKBP-51 antibody
    • FKBP5 antibody
    • FKBP5_HUMAN antibody
    • FKBP54 antibody
    • HSP90 binding immunophilin antibody
    • HSP90-binding immunophilin antibody
    • MGC111006 antibody
    • OTTHUMP00000016268 antibody
    • P54 antibody
    • Peptidyl prolyl cis trans isomerase antibody
    • Peptidyl-prolyl cis-trans isomerase FKBP5 antibody
    • Peptidylprolyl cis trans isomerase antibody
    • PPIase antibody
    • PPIase FKBP5 antibody
    • Ptg 10 antibody
    • Ptg10 antibody
    • Rotamase antibody
    • T cell FK506 binding protein antibody
    see all

Anti-FKBP51 antibody images

  • Western blot of FKBP51 on HeLa cell lysate using ab2901.

References for Anti-FKBP51 antibody (ab2901)

This product has been referenced in:
  • Allan AM  et al. Prenatal alcohol exposure modifies glucocorticoid receptor subcellular distribution in the medial prefrontal cortex and impairs frontal cortex-dependent learning. PLoS One 9:e96200 (2014). WB ; Mouse . Read more (PubMed: 24755652) »
  • Hadamitzky M  et al. Acute systemic rapamycin induces neurobehavioral alterations in rats. Behav Brain Res 273:16-22 (2014). Read more (PubMed: 25043732) »

See all 7 Publications for this product

Product Wall

Merci pour votre enquête.

A ma connaissance, il n'existent pas des isoformes décrites de FKBP51. Il existent par contre des sites de phosphorylation. Un doublet de la bande autour de 50kD pourrait donc être du à phos...

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Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Mouse Tissue lysate - whole (Brain Tissue)
Loading amount 40 µg
Specification Brain Tissue
Gel Running Conditions Non-reduced Denaturing (10% Bis-Tris)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C
Username

Abcam user community

Verified customer

Submitted May 27 2011

Thank you for your enquiry. We did a BLAST search on the immunizing sequence and the only FKBP that came up was 51. We do not think this is 12 but it may be a degraded fragment from 51.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"