• Product nameAnti-FKBP52 antibody
    See all FKBP52 primary antibodies
  • Description
    Rabbit polyclonal to FKBP52
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Rabbit, Guinea pig, Cow, Pig, Chimpanzee, Rhesus monkey, Opossum, Corn, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal residues 1 - 50 of Human FKBP52 (NP_002005.1)

  • Positive control
    • Human breast, colon, ovarian or prostate carcinomas.


Our Abpromise guarantee covers the use of ab84536 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer may optmize staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionImmunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.
    • Tissue specificityWidely expressed.
    • Sequence similaritiesContains 2 PPIase FKBP-type domains.
      Contains 3 TPR repeats.
    • DomainThe PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA).
      The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.
      The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.
    • Post-translational
      Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationCytoplasm > cytosol. Nucleus. Cytoplasm > cytoskeleton.
    • Information by UniProt
    • Database links
    • Alternative names
      • 51 kDa FK506-binding protein antibody
      • 52 kDa FK506 binding protein antibody
      • 52 kDa FK506-binding protein antibody
      • 52 kDa FKBP antibody
      • 59 kDa immunophilin antibody
      • FK506 binding protein 4 antibody
      • FK506-binding protein 4 antibody
      • FKBP 4 antibody
      • FKBP 52 antibody
      • FKBP 59 antibody
      • FKBP-4 antibody
      • FKBP-52 antibody
      • FKBP4 antibody
      • FKBP4_HUMAN antibody
      • FKBP51 antibody
      • FKBP52 protein antibody
      • FKBP59 antibody
      • HBI antibody
      • Hsp 56 antibody
      • HSP binding immunophilin antibody
      • HSP-binding immunophilin antibody
      • Hsp56 antibody
      • Immunophilin FKBP52 antibody
      • N-terminally processed antibody
      • p52 antibody
      • p59 antibody
      • p59 protein antibody
      • Peptidyl prolyl cis trans isomerase antibody
      • Peptidyl-prolyl cis-trans isomerase FKBP4 antibody
      • Peptidylprolyl cis trans isomerase antibody
      • PPIase antibody
      • PPIase FKBP4 antibody
      • Rotamase antibody
      • T cell FK506 binding protein 59kD antibody
      see all

    Anti-FKBP52 antibody images

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human prostate carcinoma tissue using 1/500 ab84536, followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human ovarian carcinoma tissue using 1/500 ab84536, followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human ovarian carcinoma tissue, using 1/100 ab84536 in conjunction with 1/100 red-fluorescent Goat anti-Rabbit IgG highly cross-adsorbed antibody Hilyte PlusTM 555.
    • Immunohistochemical analysis of Human endometrial tissue, staining FKBP52 with ab84536 at 1/300 dilution. Staining was detected using DAB.

    References for Anti-FKBP52 antibody (ab84536)

    This product has been referenced in:
    • Wang N  et al. Expression of PRB, FKBP52 and HB-EGF relating with ultrasonic evaluation of endometrial receptivity. PLoS One 7:e34010 (2012). IHC-P ; Human . Read more (PubMed: 22448285) »

    See 1 Publication for this product

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