• Product nameAnti-FKBP52 antibody
    See all FKBP52 primary antibodies
  • Description
    Mouse polyclonal to FKBP52
  • Tested applicationsSuitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human FKBP52 protein (NP_002005.1)

  • Positive control
    • Human liver tissue lysate, HeLa cell lysate, FKBP52 transfected 293T cell lysate, Human esophagus tissue, HeLa cells.

Associated products


Our Abpromise guarantee covers the use of ab88617 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa.
IHC-P Use a concentration of 3 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.
ICC/IF Use a concentration of 10 µg/ml.


  • FunctionImmunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.
  • Tissue specificityWidely expressed.
  • Sequence similaritiesContains 2 PPIase FKBP-type domains.
    Contains 3 TPR repeats.
  • DomainThe PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA).
    The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.
    The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.
  • Post-translational
    Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm > cytosol. Nucleus. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • 51 kDa FK506-binding protein antibody
    • 52 kDa FK506 binding protein antibody
    • 52 kDa FK506-binding protein antibody
    • 52 kDa FKBP antibody
    • 59 kDa immunophilin antibody
    • FK506 binding protein 4 antibody
    • FK506-binding protein 4 antibody
    • FKBP 4 antibody
    • FKBP 52 antibody
    • FKBP 59 antibody
    • FKBP-4 antibody
    • FKBP-52 antibody
    • FKBP4 antibody
    • FKBP4_HUMAN antibody
    • FKBP51 antibody
    • FKBP52 protein antibody
    • FKBP59 antibody
    • HBI antibody
    • Hsp 56 antibody
    • HSP binding immunophilin antibody
    • HSP-binding immunophilin antibody
    • Hsp56 antibody
    • Immunophilin FKBP52 antibody
    • N-terminally processed antibody
    • p52 antibody
    • p59 antibody
    • p59 protein antibody
    • Peptidyl prolyl cis trans isomerase antibody
    • Peptidyl-prolyl cis-trans isomerase FKBP4 antibody
    • Peptidylprolyl cis trans isomerase antibody
    • PPIase antibody
    • PPIase FKBP4 antibody
    • Rotamase antibody
    • T cell FK506 binding protein 59kD antibody
    see all

Anti-FKBP52 antibody images

  • Anti-FKBP52 antibody (ab88617) at 1 µg/ml + human liver tissue lysate at 50 µg

    Predicted band size : 50 kDa
    Observed band size : 60 kDa (why is the actual band size different from the predicted?)
  • Anti-FKBP52 antibody (ab88617) at 1 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 50 kDa
    Observed band size : 55 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-FKBP52 antibody (ab88617) at 1 µg/ml

    Lane 1 : FKBP52 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Predicted band size : 50 kDa
    Observed band size : 60 kDa (why is the actual band size different from the predicted?)
  • ab88617, at 3µg/ml, staining FKBP52 in formalin-fixed, paraffin-embedded human esophagus by Immunohistochemistry.
  • ab88617 at 10µg/ml staining FKBP52 in HeLa cells by Immunofluorescence.

References for Anti-FKBP52 antibody (ab88617)

ab88617 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab88617.
Please use the links above to contact us or submit feedback about this product.