The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesFlow Cyt: 1/10 - 1/100.
IHC-P: 1/100 - 1/250 antigen retrieval is recommended.
WB: 1/1000 - 1/10000. Detects a band of approximately 38 kDa (predicted molecular weight: 37 kDa).
Is unsuitable for ICC/IF or IP.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionPPIases accelerate the folding of proteins.
Tissue specificityDetected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.
Involvement in diseaseNote=FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.