Purification notesThis antibody was purified from culture supernatant of hybridoma culturedin a medium containing bovine IgG depleted fetal bovine serum (approximately 95%). Solution was filtered throgh 0.22 µm membrane.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution.
Use at an assay dependent dilution. Detects a band of approximately 37 kDa (predicted molecular weight: 56 kDa).
FunctionTranscription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
Tissue specificityUbiquitous. Higher expression in erythroid cells.
Involvement in diseaseDefects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7) [MIM:610508]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
Sequence similaritiesBelongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.