Anti-FKLF / KLF11 antibody [KLF5J027] (ab50780)

Overview

  • Product name
    Anti-FKLF / KLF11 antibody [KLF5J027]
    See all FKLF / KLF11 primary antibodies
  • Description
    Mouse monoclonal [KLF5J027] to FKLF / KLF11
  • Tested applications
    Suitable for: Dot blot, WBmore details
  • Species reactivity
    Reacts with: Recombinant fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant Human KLF11

Properties

Applications

Our Abpromise guarantee covers the use of ab50780 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Detects a band of approximately 37 kDa (predicted molecular weight: 56 kDa).

Target

  • Function
    Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
  • Tissue specificity
    Ubiquitous. Higher expression in erythroid cells.
  • Involvement in disease
    Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7) [MIM:610508]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • Sequence similarities
    Belongs to the Sp1 C2H2-type zinc-finger protein family.
    Contains 3 C2H2-type zinc fingers.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 9830142A17 antibody
    • D12Ertd427e antibody
    • FKLF antibody
    • FKLF1 antibody
    • Klf11 antibody
    • KLF11_HUMAN antibody
    • Krueppel like factor 11 antibody
    • Krueppel-like factor 11 antibody
    • Krueppel-like transcription factor 1 antibody
    • MODY7 antibody
    • Tcfcp2l2 antibody
    • TGFB Early Growth Response 2 antibody
    • TGFB-inducible early growth response protein 2 antibody
    • TGFB-inducible early growth response protein 2b antibody
    • TGFB-inducible early growth response protein 3 antibody
    • TIEG 2 antibody
    • TIEG-2 antibody
    • TIEG-3 antibody
    • Tieg2b antibody
    • Transforming Growth Factor Beta Inducible Early Growth Response 2 antibody
    • Transforming growth factor-beta-inducible early growth response protein 2 antibody
    • Transforming growth factor-beta-inducible early growth response protein 3 antibody
    see all

Images

References

ab50780 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab50780.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up