• Product nameAnti-FLAP antibody
    See all FLAP primary antibodies
  • Description
    Rabbit polyclonal to FLAP
  • Tested applicationsSuitable for: IHC-P, WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the center region of Human FLAP.

  • Positive control
    • K562 cell line lysate.


Associated products


Our Abpromise guarantee covers the use of ab80222 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50.
WB 1/50 - 1/100. Predicted molecular weight: 18 kDa.
ELISA 1/1000.


  • FunctionRequired for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
  • Involvement in diseaseGenetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
    Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition.
  • Sequence similaritiesBelongs to the MAPEG family.
  • DomainThe C-terminal part after residue 140 is mostly unstructured.
  • Cellular localizationNucleus membrane. Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5-lipoxygenase activating protein antibody
    • AL5AP_HUMAN antibody
    • ALOX 5AP antibody
    • ALOX5 AP antibody
    • ALOX5AP antibody
    • Arachidonate 5 lipoxygenase activating protein antibody
    • Arachidonate 5-lipoxygenase-activating protein antibody
    • Five lipoxygenase activating protein antibody
    • FLAP antibody
    • MK 886 binding protein antibody
    • MK-886-binding protein antibody
    see all

Anti-FLAP antibody images

  • Anti-FLAP antibody (ab80222) at 1/50 dilution + K562 cell line lysate at 35 µg

    Predicted band size : 18 kDa
    Observed band size : 16 kDa (why is the actual band size different from the predicted?)
  • ab80222 at 1/50 dilution staining FLAP in human lung carcinoma tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections). A peroxidase conjugated secondary antibody was used followed by DAB staining.

References for Anti-FLAP antibody (ab80222)

ab80222 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab80222.
Please use the links above to contact us or submit feedback about this product.