Overview

  • Product name
  • Description
    Mouse polyclonal to FLIP
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human FLIP (AAH01602).

  • Positive control
    • Human placenta

Properties

Applications

Our Abpromise guarantee covers the use of ab93037 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/500 - 1/1000. Predicted molecular weight: 55 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
    • Tissue specificity
      Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
    • Sequence similarities
      Belongs to the peptidase C14A family.
      Contains 2 DED (death effector) domains.
    • Domain
      The caspase domain lacks the active sites residues involved in catalysis.
    • Post-translational
      modifications
      Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.
    • Information by UniProt
    • Database links
    • Alternative names
      • c FLIP antibody
      • c FLIPL antibody
      • c FLIPR antibody
      • c FLIPS antibody
      • c-FLIP antibody
      • c-FLIPL antibody
      • c-FLIPR antibody
      • c-FLIPS antibody
      • CASH antibody
      • CASP8 and FADD like apoptosis regulator antibody
      • CASP8 and FADD-like apoptosis regulator subunit p12 antibody
      • CASP8AP1 antibody
      • Caspase homolog antibody
      • Caspase like apoptosis regulatory protein antibody
      • Caspase related inducer of apoptosis antibody
      • Caspase-eight-related protein antibody
      • Caspase-like apoptosis regulatory protein antibody
      • Casper antibody
      • Cellular FLICE-like inhibitory protein antibody
      • CFLA antibody
      • Cflar antibody
      • CFLAR_HUMAN antibody
      • CLARP antibody
      • FADD like anti apoptotic molecule antibody
      • FADD-like antiapoptotic molecule 1 antibody
      • FLAME antibody
      • FLAME-1 antibody
      • FLAME1 antibody
      • FLIP antibody
      • I FLICE antibody
      • I-FLICE antibody
      • Inhibitor of FLICE antibody
      • MACH-related inducer of toxicity antibody
      • MRIT antibody
      • OTTHUMP00000163715 antibody
      • OTTHUMP00000206475 antibody
      • OTTHUMP00000206476 antibody
      • OTTHUMP00000206478 antibody
      • OTTHUMP00000206479 antibody
      • OTTHUMP00000206480 antibody
      • OTTHUMP00000206482 antibody
      • OTTHUMP00000207360 antibody
      • Usurpin antibody
      • Usurpin beta antibody
      see all

    Images

    • Anti-FLIP antibody (ab93037) at 1/500 dilution + Human placenta tissue lysate at 50 µg

      Predicted band size : 55 kDa
    • All lanes : Anti-FLIP antibody (ab93037) at 1/500 dilution

      Lane 1 : FLIP transfected 293T cell line lysate
      Lane 2 : Non transfected 293T cell line lysate

      Lysates/proteins at 25 µg per lane.


      Predicted band size : 55 kDa

    References

    ab93037 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab93037.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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