Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab8129 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

General Info

  • Alternative names
    • c FLIP
    • c FLIPL
    • c FLIPR
    • c FLIPS
    • c-FLIP
    • c-FLIPL
    • c-FLIPR
    • c-FLIPS
    • CASH
    • CASP8 and FADD like apoptosis regulator
    • CASP8 and FADD-like apoptosis regulator subunit p12
    • CASP8AP1
    • Caspase homolog
    • Caspase like apoptosis regulatory protein
    • Caspase related inducer of apoptosis
    • Caspase-eight-related protein
    • Caspase-like apoptosis regulatory protein
    • Casper
    • Cellular FLICE-like inhibitory protein
    • CFLA
    • Cflar
    • CFLAR_HUMAN
    • CLARP
    • FADD like anti apoptotic molecule
    • FADD-like antiapoptotic molecule 1
    • FLAME
    • FLAME-1
    • FLAME1
    • FLIP
    • I FLICE
    • I-FLICE
    • Inhibitor of FLICE
    • MACH-related inducer of toxicity
    • MRIT
    • OTTHUMP00000163715
    • OTTHUMP00000206475
    • OTTHUMP00000206476
    • OTTHUMP00000206478
    • OTTHUMP00000206479
    • OTTHUMP00000206480
    • OTTHUMP00000206482
    • OTTHUMP00000207360
    • Usurpin
    • Usurpin beta
    see all
  • Function
    Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
  • Tissue specificity
    Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
  • Sequence similarities
    Belongs to the peptidase C14A family.
    Contains 2 DED (death effector) domains.
  • Domain
    The caspase domain lacks the active sites residues involved in catalysis.
  • Post-translational
    modifications
    Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.
  • Information by UniProt

References

ab8129 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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