Overview

  • Product name
  • Description
    Rabbit polyclonal to FLJ36733
  • Tested applications
    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: SNSSHKCQAD IRHILNKNGG VMAVGARHSF DKKGVIVVEV EDREKKAVNL ERALEMAIEA GAEDVKETED E, corresponding to amino acids 154-224 of Human FLJ36733.

  • Positive control
    • Human bone marrow tissue; RT-4 and U-251 MG cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab121805 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.
WB 1/250 - 1/500.
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval.

Target

  • Function
    Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.
  • Involvement in disease
    Defects in TACO1 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency.
  • Sequence similarities
    Belongs to the TACO1 family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • CCDC44 antibody
    • CDNA FLJ36733 fis antibody
    • Coiled coil domain containing 44 antibody
    • Coiled-coil domain-containing protein 44 antibody
    • PRO0477 antibody
    • Taco1 antibody
    • TACO1_HUMAN antibody
    • Translational activator of cytochrome c oxidase 1 antibody
    • Translational activator of mitochondrially-encoded cytochrome c oxidase I antibody
    • UTERU2012856 antibody
    see all

Images

  • Immunocytochemistry/immunofluorescence analysis of U2OS cells labelling FLJ36733 with ab121805 shows positive staining in the nucleus and mitochondria.
  • ab121805, at 1/25 dilution, staining FLJ36733 in paraffin-embedded Human bone marrow tissue by Immunohistochemistry.
  • All lanes : Anti-FLJ36733 antibody (ab121805) at 1/250 dilution

    Lane 1 : RT-4 cell lysate
    Lane 2 : U-251 MG cell lysate
    Lane 3 : Human Plasma lysate
    Lane 4 : Human Liver lysate
    Lane 5 : Human Tonsil lysate

References

ab121805 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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