FunctionNeuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution.
Tissue specificityWidely expressed. Expressed at lower level in liver and kidney.
Sequence similaritiesBelongs to the RILPL family. Contains 1 RILP-like domain.
Post-translational modificationsS-nitrosylation is required for the interaction with GAPDH.