Overview

  • Product name
  • Description
    Rabbit polyclonal to FLJ39378
  • Tested applications
    Suitable for: ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    17 amino acid synthetic peptide derived from near the N terminal of Human FLJ39378 (AAH89444).

  • Positive control
    • Rat cerebellum tissue lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab117441 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 47 kDa.

Target

  • Function
    Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution.
  • Tissue specificity
    Widely expressed. Expressed at lower level in liver and kidney.
  • Sequence similarities
    Belongs to the RILPL family.
    Contains 1 RILP-like domain.
  • Post-translational
    modifications
    S-nitrosylation is required for the interaction with GAPDH.
  • Cellular localization
    Cytoplasm > cytosol.
  • Information by UniProt
  • Database links
  • Alternative names
    • GOSPEL antibody
    • MGC105128 antibody
    • MGC99793 antibody
    • Rab interacting lysosomal protein like 1 antibody
    • Rab-interacting lysosomal-like protein 1 antibody
    • RILP like protein 1 antibody
    • RILP-like protein 1 antibody
    • RILPL 1 antibody
    • rilpl1 antibody
    • RIPL1_HUMAN antibody
    • RLP1 antibody
    see all

Images

  • Lane 1 : Anti-FLJ39378 antibody (ab117441) at 0.5 µg/ml
    Lane 2 : Anti-FLJ39378 antibody (ab117441) at 1 µg/ml

    Lane 1 : Rat cerebellum tissue lysate
    Lane 2 : Rat cerebellum tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 47 kDa
  • Immunofluorescence analysis of mouse brain cells, staining FLJ39378 with ab117441 at 20 µg/ml.

References

ab117441 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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