Overview

  • Product name
    Flufenamic acid
  • Description
    NSAID. COX inhibitor, channel blocker.
  • Biological description
    Non-steroidal anti-inflammatory. Potently inhibits human transthyretin amyloid fibril formation. Alters ion fluxes through the plasma membrane. Potent non-specific blocker of cation and anion channels, commonly used to block currents through TRP channels and receptor-operated channels.
  • Purity
    > 98%

Properties

Applications

Our Abpromise guarantee covers the use of ab120354 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.

Images

  • ab51110 staining AMPKα 1 + AMPKα 2 (phosphoT172) in HeLa cells treated with flufenamic acid (ab120354), by ICC/IF. Increase in AMPKα 1 + AMPKα 2 (phosphoT172) nuclear expression correlates with increased concentration of flufenamic acid, as described in literature.
    The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab120354 (flufenamic acid) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab51110 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

References

This product has been referenced in:
  • Hotta A  et al. The effects of flufenamic acid on spontaneous activity of smooth muscle tissue isolated from the guinea-pig stomach antrum. J Smooth Muscle Res 41:207-20 (2005). Read more (PubMed: 16258234) »
  • Peterson SA  et al. Inhibiting transthyretin conformational changes that lead to amyloid fibril formation. Proc Natl Acad Sci U S A 95:12956-60 (1998). Read more (PubMed: 9789022) »
  • Flower RJ Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev 26:33-67 (1974). Read more (PubMed: 4208101) »
  • Tu P  et al. The anti-inflammatory agent flufenamic acid depresses store-operated channels by altering mitochondrial calcium homeostasis. Neuropharmacology 56:1010-6 (0). Read more (PubMed: 19233217) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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