Overview

  • Product name
    Flumethasone
  • Description
    Glucocorticoid receptor agonist
  • Biological description
    Glucocorticoid receptor agonist. Inhibits platelet-activating factor-induced aggregation. Shows anti-inflammatory, antipruritic and vasoconstrictive effects in vivo.
  • Purity
    > 99%

Properties

  • Chemical name
    (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • Molecular weight
    410.45
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C22H28F2O5
  • CAS Number
    2135-17-3
  • PubChem identifier
    16490
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 10 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Miolo G  et al. Photoactivation of corticosteroids in UVB-exposed skin. J Photochem Photobiol B 103:35-41 (2011). Read more (PubMed: 21324709) »
  • Malone EM  et al. Development of a rapid method for the analysis of synthetic growth promoters in bovine muscle using liquid chromatography tandem mass spectrometry. Anal Chim Acta 637:112-20 (2009). Read more (PubMed: 19286019) »
  • Zwahlen RD  et al. In vitro aggregation of bovine neonatal neutrophils. A comparative study with adult cattle. Inflammation 14:375-87 (1990). Read more (PubMed: 2379953) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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