Overview

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab72421 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100.

Target

  • FunctionRequired for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Protects cells against apoptosis by protecting CDKN1A against degradation.
  • Tissue specificityExpressed almost exclusively in the developing and mature central nervous system.
  • Sequence similaritiesBelongs to the formin homology family. Cappuccino subfamily.
    Contains 1 FH1 (formin homology 1) domain.
    Contains 1 FH2 (formin homology 2) domain.
  • Cellular localizationCytoplasm > cytoskeleton. Cytoplasm > perinuclear region. Cytoplasm > cytosol. Cell membrane. Cytoplasmic vesicle membrane. Cytoplasm > cell cortex. Nucleus > nucleolus. Recruited to the membranes via its interaction with SPIRE1. Colocalizes with the actin cytoskeleton. Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion.
  • Information by UniProt
  • Database links
  • Alternative names
    • FMN 2 antibody
    • Fmn2 antibody
    • FMN2_HUMAN antibody
    • Formin 2 antibody
    • Formin-2 antibody
    see all

Anti-FMN2 antibody images

  • Immunohistochemical analysis of FMN2 in paraffin-embedded formalin-fixed human uterus tissue using an isotype control (top) and ab72421 (bottom) at 1:100.

References for Anti-FMN2 antibody (ab72421)

ab72421 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"