Overview

  • Product name
    Anti-FMNL1 antibody [2369E4a]
    See all FMNL1 primary antibodies
  • Description
    Mouse monoclonal [2369E4a] to FMNL1
  • Tested applications
    Suitable for: WB, Dot blotmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    FMNL1 recombinant fragment (Human)

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    ab54361 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane.
  • Clonality
    Monoclonal
  • Clone number
    2369E4a
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab54361 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 122 kDa.
Dot blot Use at an assay dependent dilution.

Target

  • Function
    May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
  • Tissue specificity
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • Sequence similarities
    Belongs to the formin homology family.
    Contains 1 DAD (diaphanous autoregulatory) domain.
    Contains 1 FH2 (formin homology 2) domain.
    Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
  • Domain
    The DAD domain regulates activation via by an autoinhibitory interaction with the N-terminus. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.
  • Post-translational
    modifications
    Myristoylation mediates membrane localization and blebbing.
  • Cellular localization
    Cytoplasm > cell cortex. Cell projection > bleb. Colocalized with F-actin in bleb protrusions and Cytoplasm. Cell membrane. Cytoplasmic vesicle > phagosome. Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1.
  • Information by UniProt
  • Database links
  • Alternative names
    • 8030453N10Rik antibody
    • AI553564 antibody
    • C17orf1 antibody
    • C17orf1B antibody
    • CLL associated antigen KW 13 antibody
    • CLL-associated antigen KW-13 antibody
    • FHOD4 antibody
    • FMNL antibody
    • FMNL_HUMAN antibody
    • Fmnl1 antibody
    • Fnrl antibody
    • Formin like 1 antibody
    • Formin like antibody
    • Formin related protein antibody
    • Formin-like protein 1 antibody
    • Frls antibody
    • KW 13 antibody
    • KW13 antibody
    • Leukocyte formin antibody
    • MGC133052 antibody
    • MGC1894 antibody
    • MGC21878 antibody
    see all

Images

References

ab54361 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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