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Function
May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
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Tissue specificity
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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Sequence similarities
Belongs to the formin homology family.
Contains 1 DAD (diaphanous autoregulatory) domain.
Contains 1 FH2 (formin homology 2) domain.
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
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Domain
The DAD domain regulates activation via by an autoinhibitory interaction with the N-terminus. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.
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Post-translational
modifications
Myristoylation mediates membrane localization and blebbing.
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Cellular localization
Cytoplasm > cell cortex. Cell projection > bleb. Colocalized with F-actin in bleb protrusions and Cytoplasm. Cell membrane. Cytoplasmic vesicle > phagosome. Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1.
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Information by UniProt
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Database links
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Alternative names
- 8030453N10Rik antibody
- AI553564 antibody
- C17orf1 antibody
- C17orf1B antibody
- CLL associated antigen KW 13 antibody
- CLL-associated antigen KW-13 antibody
- FHOD4 antibody
- FMNL antibody
- FMNL_HUMAN antibody
- Fmnl1 antibody
- Fnrl antibody
- Formin like 1 antibody
- Formin like antibody
- Formin related protein antibody
- Formin-like protein 1 antibody
- Frls antibody
- KW 13 antibody
- KW13 antibody
- Leukocyte formin antibody
- MGC133052 antibody
- MGC1894 antibody
- MGC21878 antibody
see all