Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA).
Use at an assay dependent dilution. Predicted molecular weight: 110 kDa.Can be blocked with Human FNBP3 peptide (ab23236). Preliminary experiments gave an ~28kDa band in A549 lysates at 1ug/ml, this band was successfully blocked by incubation with the immunising peptide. Please note that currently we cannot find a definitive explanation in the literature for the band we observe given the predicted size of ~110kDda.
FunctionBinds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). May be involved in pre-mRNA splicing.
Tissue specificityExpressed in the brain cortex (at protein level). Widely expressed.
Sequence similaritiesBelongs to the PRPF40 family. Contains 5 FF domains. Contains 2 WW domains.
DomainThe WW domains are essential for localization to nuclear speckles.
Cellular localizationNucleus speckle. Nucleus matrix. Colocalizes with AKAP8L in the nuclear matrix.