Anti-FNDC5 antibody - C-terminal (ab181884)
Key features and details
- Rabbit polyclonal to FNDC5 - C-terminal
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-FNDC5 antibody - C-terminal
See all FNDC5 primary antibodies -
Description
Rabbit polyclonal to FNDC5 - C-terminal -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide within Human FNDC5 (C terminal). The exact sequence is proprietary.
Database link: Q8NAU1 -
Positive control
- Recombinant Human FNDC5 protein (ab132900) can be used as a positive control in WB.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Constituents: 1.21% Tris, 0.75% Glycine, 2% Sucrose -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab181884 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P | (1) |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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Notes |
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IHC-P
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
Target
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Sequence similarities
Contains 1 fibronectin type-III domain. -
Cellular localization
Peroxisome membrane. Imported in peroxisomes through the PEX5 receptor pathway. - Information by UniProt
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Database links
- Entrez Gene: 252995 Human
- Entrez Gene: 384061 Mouse
- Entrez Gene: 260327 Rat
- Omim: 611906 Human
- SwissProt: Q8NAU1 Human
- SwissProt: Q8K4Z2 Mouse
- SwissProt: Q8K3V5 Rat
- Unigene: 524234 Human
see all -
Alternative names
- Fibronectin type III domain containing 5 antibody
- Fibronectin type III domain-containing protein 5 antibody
- Fibronectin type III repeat containing protein 2 antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab181884 has been referenced in 8 publications.
- Liu H et al. FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells. Front Oncol 12:852095 (2022). PubMed: 35392237
- Yang Y et al. FNDC5/irisin is expressed and regulated differently in human periodontal ligament cells, dental pulp stem cells and osteoblasts. Arch Oral Biol 124:105061 (2021). PubMed: 33508625
- Wang FS et al. Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy. Antioxidants (Basel) 9:N/A (2020). PubMed: 32882839
- Chemello F et al. Transcriptomic Analysis of Single Isolated Myofibers Identifies miR-27a-3p and miR-142-3p as Regulators of Metabolism in Skeletal Muscle. Cell Rep 26:3784-3797.e8 (2019). PubMed: 30917329
- Pan YJ et al. Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure. Kidney Blood Press Res 44:479-495 (2019). PubMed: 31238319
- Amengual J et al. Retinoic Acid Increases Fatty Acid Oxidation and Irisin Expression in Skeletal Muscle Cells and Impacts Irisin In Vivo. Cell Physiol Biochem 46:187-202 (2018). PubMed: 29587291
- Timurkaan S et al. Identification of irisin immunoreactivity in porcupine (Hystrix cristata) adrenal glands and kidneys. Anat Histol Embryol 47:405-409 (2018). PubMed: 29862553
- Hassanzadeh S et al. FNDC5 expression in Purkinje neurons of adult male rats with acute spinal cord injury following treatment with methylprednisolone. Neuropeptides 70:16-25 (2018). PubMed: 29907375