Recombinant Anti-FNTA antibody [EPR4704] (ab109738)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR4704] to FNTA
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
Related conjugates and formulations
Overview
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Product name
Anti-FNTA antibody [EPR4704]
See all FNTA primary antibodies -
Description
Rabbit monoclonal [EPR4704] to FNTA -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: ICC/IF or IP -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- Jurkat, HeLa, JAR, C6, RAW264.7, PC12, and NIH3T3 cell lysates.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
EPR4704 -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab109738 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/1000 - 1/10000. Predicted molecular weight: 44 kDa.
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Notes |
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WB
1/1000 - 1/10000. Predicted molecular weight: 44 kDa. |
Target
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Function
Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK. -
Sequence similarities
Belongs to the protein prenyltransferase subunit alpha family.
Contains 5 PFTA repeats. -
Post-translational
modificationsPhosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA. - Information by UniProt
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Database links
- Entrez Gene: 2339 Human
- Entrez Gene: 14272 Mouse
- Entrez Gene: 25318 Rat
- Omim: 134635 Human
- SwissProt: P49354 Human
- SwissProt: Q61239 Mouse
- SwissProt: Q04631 Rat
- Unigene: 370312 Human
see all -
Alternative names
- CAAX farnesyltransferase alpha subunit antibody
- CAAX farnesyltransferase subunit alpha antibody
- EC 2.5.1.58 antibody
see all
Images
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All lanes : Anti-FNTA antibody [EPR4704] (ab109738) at 1/1000 dilution
Lane 1 : Jurkat cell lysate
Lane 2 : HeLa cell lysate
Lane 3 : JAR cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 44 kDa -
All lanes : Anti-FNTA antibody [EPR4704] (ab109738) at 1/1000 dilution
Lane 1 : C6 cell lysate
Lane 2 : RAW264.7 cell lysate
Lane 3 : PC12 cell lysate
Lane 4 : NIH3T3 cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 44 kDa
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab109738 has been referenced in 4 publications.
- Pinner AL et al. Protein expression of prenyltransferase subunits in postmortem schizophrenia dorsolateral prefrontal cortex. Transl Psychiatry 10:3 (2020). PubMed: 32066669
- Jiang D et al. Expression of key enzymes in the mevalonate pathway are altered in monocrotaline-induced pulmonary arterial hypertension in rats. Mol Med Rep 16:9593-9600 (2017). PubMed: 29039598
- Miles RR et al. Genome-wide screen for modulation of hepatic apolipoprotein A-I (ApoA-I) secretion. J Biol Chem 288:6386-96 (2013). WB ; Human . PubMed: 23322769
- Cieslik KA et al. Aberrant differentiation of fibroblast progenitors contributes to fibrosis in the aged murine heart: role of elevated circulating insulin levels. FASEB J 27:1761-71 (2013). PubMed: 23303205