Overview

  • Product name
  • Description
    Rabbit polyclonal to FOG1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla
  • Immunogen

    Synthetic peptide corresponding to a region between residue 175 and 225 of human FOG1 (accession number: NP_722520.2)

  • Positive control
    • Human Controls: Breast Carcinoma, Hodgkins Lymphoma, Prostate Carcinoma

Properties

Applications

Our Abpromise guarantee covers the use of ab84876 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
    • Tissue specificity
      Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.
    • Sequence similarities
      Belongs to the FOG (Friend of GATA) family.
      Contains 4 C2H2-type zinc fingers.
      Contains 5 C2HC-type zinc fingers.
    • Domain
      The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • FOG-1 antibody
      • FOG1_HUMAN antibody
      • Friend of GATA 1 antibody
      • Friend of GATA protein 1 antibody
      • Friend of GATA1 antibody
      • ZFPM1 antibody
      • Zinc finger protein antibody
      • Zinc finger protein 89A antibody
      • Zinc finger protein multitype 1 antibody
      • Zinc finger protein ZFPM1 antibody
      see all

    Anti-FOG1 antibody images

    • Detection of Human FOG1 in formalin-fixed paraffin-embedded section of human Hodgkin's Lymphoma by Immunohistochemistry using ab84876 at a dilution of 1:250. Detection: DAB staining.
    • Detection of Human FOG1 in formalin-fixed paraffin-embedded section of human breast carcinoma by Immunohistochemistry using ab84876 at a dilution of 1:250. Detection: DAB staining.

    References for Anti-FOG1 antibody (ab84876)

    ab84876 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab84876.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up