Overview

  • Product nameAnti-FOG2 antibody
    See all FOG2 primary antibodies
  • Description
    Rabbit polyclonal to FOG2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C-terminal amino acids 882-911 of Human FOG2 (NP_036214.20.

  • Positive control
    • Hela cell line lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab123879 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 128 kDa.

Target

  • FunctionTranscription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.
  • Tissue specificityWidely expressed at low level.
  • Involvement in diseaseDefects in ZFPM2 may be a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
    Defects in ZFPM2 are the cause of diaphragmatic hernia 3 (DIH3) [MIM:610187]; a form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension.
  • Sequence similaritiesBelongs to the FOG (Friend of GATA) family.
    Contains 3 C2H2-type zinc fingers.
    Contains 5 C2HC-type zinc fingers.
  • DomainThe CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • FOG-2 antibody
    • FOG2_HUMAN antibody
    • Friend of GATA 2 antibody
    • Friend of GATA protein 2 antibody
    • Friend of GATA2 antibody
    • hFOG-2 antibody
    • ZFPM2 antibody
    • Zinc finger protein 89B antibody
    • Zinc finger protein M2 antibody
    • Zinc finger protein multitype 2 antibody
    • Zinc finger protein ZFPM2 antibody
    see all

Anti-FOG2 antibody images

  • Anti-FOG2 antibody (ab123879) at 1/100 dilution + Hela cell line lysate at 35 µg

    Predicted band size : 128 kDa

References for Anti-FOG2 antibody (ab123879)

ab123879 has not yet been referenced specifically in any publications.

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