Anti-Folate Binding Protein antibody (HRP) - Azide free (ab20572)

Overview

  • Product nameAnti-Folate Binding Protein antibody (HRP) - Azide free
    See all Folate Binding Protein primary antibodies
  • Description
    Goat polyclonal to Folate Binding Protein - Azide free (HRP)
  • ConjugationHRP
  • SpecificityThis antibody targets both purified and partially purified Folate Binding Protein from bovine milk.
  • Tested applicationsSuitable for: WB, Dot blot, ELISA, IHC-P, IHC-Fr, Immunomicroscopymore details
  • Species reactivity
    Reacts with: Cow
  • Immunogen

    Folate Binding Protein (bovine milk).

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C.
  • Storage bufferPreservative: 0.01% Gentamicin Sulfate
    Constituents: PBS, 10mg/ml Polyethylene glycol (PEG 8000). pH 7.2
  • Concentration information loading...
  • Purification notesPurified from monospecific antiserum by delipidation, fractionation and ion exchange chromatography.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab20572 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.
Dot blot Use at an assay dependent dilution.
ELISA 1/2000 - 1/12000.
IHC-P 1/100 - 1/200.
IHC-Fr 1/100 - 1/200.
Immunomicroscopy Use at an assay dependent dilution.

Target

  • FunctionBinds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
  • Tissue specificityExclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.
  • Involvement in diseaseDefects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function.
  • Sequence similaritiesBelongs to the folate receptor family.
  • Post-translational
    modifications
    Eight disulfide bonds are present.
    The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
  • Cellular localizationCell membrane. Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • adult antibody
    • Adult folate binding protein antibody
    • Adult folate-binding protein antibody
    • FBP antibody
    • Folate Receptor 1 Adult antibody
    • Folate receptor 1 antibody
    • Folate Receptor 1 Precursor antibody
    • Folate receptor adult antibody
    • Folate receptor alpha antibody
    • Folate receptor antibody
    • FOLR antibody
    • FOLR1 antibody
    • FOLR1_HUMAN antibody
    • FR alpha antibody
    • FR-alpha antibody
    • FRalpha antibody
    • KB cells FBP antibody
    • MOV18 antibody
    • Ovarian cancer associated antigen antibody
    • Ovarian tumor associated antigen antibody
    • Ovarian tumor associated antigen MOv18 antibody
    • Ovarian tumor-associated antigen MOv18 antibody
    see all

Anti-Folate Binding Protein antibody (HRP) - Azide free images

  • Immunohistochemical analysis of Human clear cell ovarian carcinoma tissue, staining Folate Binding Protein with ab20572 at 1/200 dilution.

References for Anti-Folate Binding Protein antibody (HRP) - Azide free (ab20572)

This product has been referenced in:
  • Siu MK  et al. Paradoxical impact of two folate receptors, FRa and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome. PLoS One 7:e47201 (2012). IHC-P . Read more (PubMed: 23144806) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab20572.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"