Anti-Folate Binding Protein antibody (HRP) - Azide free (ab20572)

Overview

  • Product name
    Anti-Folate Binding Protein antibody (HRP) - Azide free
    See all Folate Binding Protein primary antibodies
  • Description
    Goat polyclonal to Folate Binding Protein - Azide free (HRP)
  • Conjugation
    HRP
  • Specificity
    This antibody targets both purified and partially purified Folate Binding Protein from bovine milk.
  • Tested applications
    Suitable for: WB, Dot blot, ELISA, IHC-P, IHC-Fr, Immunomicroscopymore details
  • Species reactivity
    Reacts with: Cow
  • Immunogen

    Folate Binding Protein (bovine milk).

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 0.01% Gentamicin Sulfate
    Constituents: PBS, 10mg/ml Polyethylene glycol (PEG 8000). pH 7.2
  • Concentration information loading...
  • Purification notes
    Purified from monospecific antiserum by delipidation, fractionation and ion exchange chromatography.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab20572 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.
Dot blot Use at an assay dependent dilution.
ELISA 1/2000 - 1/12000.
IHC-P 1/100 - 1/200.
IHC-Fr 1/100 - 1/200.
Immunomicroscopy Use at an assay dependent dilution.

Target

  • Function
    Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
  • Tissue specificity
    Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.
  • Involvement in disease
    Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function.
  • Sequence similarities
    Belongs to the folate receptor family.
  • Post-translational
    modifications
    Eight disulfide bonds are present.
    The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
  • Cellular localization
    Cell membrane. Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • adult antibody
    • Adult folate binding protein antibody
    • Adult folate-binding protein antibody
    • FBP antibody
    • Folate Receptor 1 Adult antibody
    • Folate receptor 1 antibody
    • Folate Receptor 1 Precursor antibody
    • Folate receptor adult antibody
    • Folate receptor alpha antibody
    • Folate receptor antibody
    • FOLR antibody
    • FOLR1 antibody
    • FOLR1_HUMAN antibody
    • FR alpha antibody
    • FR-alpha antibody
    • FRalpha antibody
    • KB cells FBP antibody
    • MOV18 antibody
    • Ovarian cancer associated antigen antibody
    • Ovarian tumor associated antigen antibody
    • Ovarian tumor associated antigen MOv18 antibody
    • Ovarian tumor-associated antigen MOv18 antibody
    see all

Images

  • Immunohistochemical analysis of Human clear cell ovarian carcinoma tissue, staining Folate Binding Protein with ab20572 at 1/200 dilution.

References

This product has been referenced in:
  • Siu MK  et al. Paradoxical impact of two folate receptors, FRa and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome. PLoS One 7:e47201 (2012). IHC-P . Read more (PubMed: 23144806) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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