Anti-Folate Binding Protein/FBP antibody [LK26] (ab3361)
Key features and details
- Mouse monoclonal [LK26] to Folate Binding Protein/FBP
- Suitable for: IHC-Fr
- Reacts with: Human
- Isotype: IgG2a
Overview
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Product name
Anti-Folate Binding Protein/FBP antibody [LK26]
See all Folate Binding Protein/FBP primary antibodies -
Description
Mouse monoclonal [LK26] to Folate Binding Protein/FBP -
Host species
Mouse -
Tested applications
Suitable for: IHC-Frmore details -
Species reactivity
Reacts with: Human -
Immunogen
Tissue, cells or virus. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- Frozen Placenta or Ovarian Carcinoma (Negative control: Mouse serum or IgG1 isotype-matched negative control antibody, diluted to the same concentration as the primary antibody, should also be included in each run.)
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituents: 1% BSA, PBS -
Concentration information loading...
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Purity
Affinity purified -
Clonality
Monoclonal -
Clone number
LK26 -
Isotype
IgG2a -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab3361 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-Fr |
1/40.
|
Notes |
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IHC-Fr
1/40. |
Target
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Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. -
Tissue specificity
Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. -
Involvement in disease
Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. -
Sequence similarities
Belongs to the folate receptor family. -
Post-translational
modificationsEight disulfide bonds are present.
The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. -
Cellular localization
Cell membrane. Secreted. - Information by UniProt
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Database links
- Entrez Gene: 2348 Human
- Omim: 136430 Human
- SwissProt: P15328 Human
- Unigene: 73769 Human
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Alternative names
- adult antibody
- Adult folate binding protein antibody
- Adult folate-binding protein antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (15)
ab3361 has been referenced in 15 publications.
- Gowda P et al. Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer. Inflammation 45:172-179 (2022). PubMed: 34480250
- Skubalova Z et al. Passive Diffusion vs Active pH-Dependent Encapsulation of Tyrosine Kinase Inhibitors Vandetanib and Lenvatinib into Folate-Targeted Ferritin Delivery System. Int J Nanomedicine 16:1-14 (2021). PubMed: 33442247
- Cui J et al. Downregulation of folate receptor a contributes to homocysteine-induced human umbilical vein endothelial cell injury via activation of endoplasmic reticulum stress. Mol Med Rep 22:1631-1638 (2020). PubMed: 32626963
- Körhegyi Z et al. Synthesis of 68Ga-Labeled Biopolymer-based Nanoparticle Imaging Agents for Positron-emission Tomography. Anticancer Res 39:2415-2427 (2019). PubMed: 31092434
- Chen J & Li L Aberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma. Anal Cell Pathol (Amst) 2019:1438628 (2019). PubMed: 31049278