Overview

  • Product name
  • Description
    Rabbit polyclonal to FOLR2
  • Tested applications
    Suitable for: Flow Cyt, WB, ELISAmore details
  • Species reactivity
    Reacts with: Human, Recombinant fragment
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to N terminal residues of human FOLR2

Properties

Applications

Our Abpromise guarantee covers the use of ab56067 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration. PubMed: 23439585ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
WB Use at an assay dependent concentration. Predicted molecular weight: 29 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent concentration.

Target

  • Function
    Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
  • Tissue specificity
    Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
  • Sequence similarities
    Belongs to the folate receptor family.
  • Post-translational
    modifications
    Eight disulfide bonds are present.
    N-glycosylated.
  • Cellular localization
    Cell membrane. Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • beta hFR antibody
    • FBP antibody
    • FBP/PL 1 antibody
    • FBP2 antibody
    • fetal/placental antibody
    • folate receptor 2 (fetal) antibody
    • Folate receptor 2 antibody
    • Folate receptor antibody
    • Folate receptor beta antibody
    • Folate receptor, fetal/placental antibody
    • Folbp 2 antibody
    • Folbp2 antibody
    • Folr2 antibody
    • FOLR2_HUMAN antibody
    • FR beta antibody
    • FR P3 antibody
    • FR-beta antibody
    • Placental folate binding protein antibody
    • Placental folate-binding protein antibody
    see all

References

This product has been referenced in:
  • Perna AF  et al. Altered folate receptor 2 expression in uraemic patients on haemodialysis: implications for folate resistance. Nephrol Dial Transplant N/A:N/A (2013). WB, Flow Cyt ; Human . Read more (PubMed: 23439585) »
  • Stronach EA  et al. HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer. Cancer Res 71:4412-22 (2011). WB ; Human . Read more (PubMed: 21571862) »

See all 2 Publications for this product

Customer reviews and Q&As

Abcam has not validated the combination of species/application used in this Abreview.
Application
Immunocytochemistry/ Immunofluorescence
Sample
Human Cell (THP-1)
Specification
THP-1
Fixative
Paraformaldehyde
Permeabilization
No
Blocking step
Protein Block (serum free) as blocking agent for 20 minute(s) · Concentration: 100% · Temperature: 4°C
Username

Mr. Alan Maziarz

Verified customer

Submitted Oct 14 2008

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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