Anti-Forkhead box protein O antibody - N-terminal (ab195977)

Overview

  • Product name
    Anti-Forkhead box protein O antibody - N-terminal
  • Description
    Rabbit polyclonal to Forkhead box protein O - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Drosophila melanogaster
  • Immunogen

    Synthetic peptide corresponding to Fruit fly (Drosophila melanogaster) Forkhead box protein O (N terminal).
    Database link: Q95V55

Properties

  • Form
    Lyophilised:Reconstitute with 100 uL distilled water.
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Constituents: 1.21% Tris buffer, 0.75% Glycine, 2% Sucrose
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG

Applications

Our Abpromise guarantee covers the use of ab195977 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 67 kDa.

Target

  • Function
    Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thor\d4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis.
  • Sequence similarities
    Contains 1 fork-head DNA-binding domain.
  • Cellular localization
    Cytoplasm. Nucleus. When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation.
  • Information by UniProt
  • Database links
    • Alternative names
      • dFOXO antibody
      • Forkhead box protein O antibody
      • foxo antibody
      • FOXO_DROME antibody
      • Protein FKHR antibody
      see all

    References

    ab195977 has not yet been referenced specifically in any publications.

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