Overview

  • Product nameAnti-FOXA3 antibody
    See all FOXA3 primary antibodies
  • Description
    Rabbit polyclonal to FOXA3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Horse, Cow, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within the C terminal amino acids 301-350 (YNFNHPFSIN NLMSEQTSTP SKLDVGFGGY GAESGEPGVY YQSLYSRSLL) of Mouse FOXA3 (NP_032286).

  • Positive control
    • Mouse brain lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab105523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 37 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionTranscription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.
  • Tissue specificityExpressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined.
  • Sequence similaritiesContains 1 fork-head DNA-binding domain.
  • Developmental stageDetected in prenatal liver nuclear extracts (12.4-27 weeks estimated gestational age). Not detected in postnatal liver samples.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • FKHH3 antibody
    • Fork head-related protein FKH H3 antibody
    • forkhead box A3 antibody
    • Forkhead box protein A3 antibody
    • Foxa3 antibody
    • FOXA3_HUMAN antibody
    • hepatic nuclear factor-3-beta antibody
    • hepatocyte nuclear factor 3 antibody
    • hepatocyte nuclear factor 3 gamma antibody
    • Hepatocyte nuclear factor 3-gamma antibody
    • HNF-3-gamma antibody
    • HNF-3G antibody
    • HNF3B antibody
    • HNF3G antibody
    • TCF-3G antibody
    • TCF3G antibody
    • Transcription factor 3G antibody
    see all

Anti-FOXA3 antibody images

  • Anti-FOXA3 antibody (ab105523) at 1 µg/ml + Mouse brain lysate at 10 µg

    Predicted band size : 37 kDa

References for Anti-FOXA3 antibody (ab105523)

ab105523 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"