Anti-FOXD3 antibody (ab67758)
Key features and details
- Rabbit polyclonal to FOXD3
- Suitable for: ChIP, WB
- Reacts with: Chicken
- Isotype: IgG
Overview
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Product name
Anti-FOXD3 antibody
See all FOXD3 primary antibodies -
Description
Rabbit polyclonal to FOXD3 -
Host species
Rabbit -
Tested applications
Suitable for: ChIP, WBmore details -
Species reactivity
Reacts with: Chicken
Predicted to work with: Mouse, Human -
Immunogen
Synthetic peptide derived from N terminal domain of chicken FOXD3 protein
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
Storage buffer
Constituent: Whole serum -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab67758 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ChIP | (1) |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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Notes |
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ChIP
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
Target
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Function
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. -
Tissue specificity
Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. -
Involvement in disease
Defects in FOXD3 are associated with susceptibility to autoimmune disease type 1 (AIS1) [MIM:607836]. AIS1 is a disorder characterized by the association of vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis). -
Sequence similarities
Contains 1 fork-head DNA-binding domain. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 395794 Chicken
- Entrez Gene: 27022 Human
- Entrez Gene: 15221 Mouse
- Omim: 611539 Human
- SwissProt: P79772 Chicken
- SwissProt: Q9UJU5 Human
- SwissProt: Q61060 Mouse
- Unigene: 546573 Human
see all -
Alternative names
- AIS1 antibody
- forkhead box D3 antibody
- Forkhead box protein D3 antibody
see all
Datasheets and documents
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Datasheet download
References (6)
ab67758 has been referenced in 6 publications.
- Wu Z et al. FOXD3 suppresses epithelial-mesenchymal transition through direct transcriptional promotion of SMAD7 in esophageal squamous cell carcinoma. Mol Carcinog 60:859-873 (2021). PubMed: 34551139
- Li R et al. The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2. Exp Mol Med 52:118-129 (2020). PubMed: 31959866
- Xu W et al. FOXD3 Suppresses Tumor-Initiating Features in Lung Cancer via Transcriptional Repression of WDR5. Stem Cells 37:582-592 (2019). PubMed: 30703266
- Zhao X et al. Risk-Associated Long Noncoding RNA FOXD3-AS1 Inhibits Neuroblastoma Progression by Repressing PARP1-Mediated Activation of CTCF. Mol Ther 26:755-773 (2018). PubMed: 29398485
- Huang J & Chen L IL-1β inhibits osteogenesis of human bone marrow-derived mesenchymal stem cells by activating FoxD3/microRNA-496 to repress wnt signaling. Genesis 55:N/A (2017). PubMed: 28509407
- Guo H et al. The aspirin-induced long non-coding RNA OLA1P2 blocks phosphorylated STAT3 homodimer formation. Genome Biol 17:24 (2016). WB ; Human . PubMed: 26898989