• Product name
  • Description
    Rabbit polyclonal to FOXE3
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from an internal region of Human FOXE3

  • Positive control
    • extracts from 562 cells



Our Abpromise guarantee covers the use of ab72596 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 33 kDa (predicted molecular weight: 33 kDa).
ELISA 1/5000.


  • Involvement in disease
    Defects in FOXE3 are a cause of anterior segment mesenchymal dysgenesis (ASMD) [MIM:107250]; also known as anterior segment ocular dysgenesis (ASOD). ASMD consists of a range of developmental defects in structures at the front of the eye, resulting from abnormal migration or differentiation of the neural crest derived mesenchymal cells that give rise to the cornea, iris, and other components of the anterior chamber during eye development. Mature anterior segment anomalies are associated with an increased risk of glaucoma and corneal opacity. Conditions falling within the phenotypic spectrum include aniridia, posterior embryotoxon, Axenfeld anomaly, Reiger anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis.
    Defects in FOXE3 are a cause of congenital primary aphakia (CPA) [MIM:610256]. Aphakia is a rare congenital eye disorder in which the lens is missing. It has been histologically subdivided into primary and secondary forms, in accordance with the severity of defects of the ocular tissues, whose development requires the initial presence of a lens. CPA results from an early developmental arrest, around the 4th-5th week of gestation in humans, that prevents the formation of any lens structure and leads to severe secondary ocular defects, including a complete aplasia of the anterior segment of the eye. In contrast, in secondary aphakic eyes, lens induction has occurred, and the lens vesicle has developed to some degree but finally has progressively resorbed perinatally, leading, therefore, to less-severe ocular defects.
  • Sequence similarities
    Contains 1 fork-head DNA-binding domain.
  • Developmental stage
    Expressed in the lens during embryonic development. Predominantly expressed in the anterior lens epithelium but with some expression posteriorly. Not expressed in brain in embryos.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • Drosphilia Forkhead Homolog Like 12 antibody
    • FKHL 12 antibody
    • FKHL12 antibody
    • Forkhead Box E3 antibody
    • Forkhead box protein E3 antibody
    • Forkhead Related Activator 8 antibody
    • Forkhead related protein FKHL12 antibody
    • Forkhead-related protein FKHL12 antibody
    • Forkhead-related transcription factor 8 antibody
    • Foxe3 antibody
    • FOXE3 forkhead box E3 antibody
    • FOXE3_HUMAN antibody
    • FREAC 8 antibody
    • FREAC-8 antibody
    • FREAC8 antibody
    see all

Anti-FOXE3 antibody images

  • All lanes : Anti-FOXE3 antibody (ab72596) at 1/500 dilution

    Lane 1 : extracts from 562 cells
    Lane 2 : extracts from 562 cells, with 10 ug of the immunising peptide

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 33 kDa
    Observed band size : 33 kDa

References for Anti-FOXE3 antibody (ab72596)

ab72596 has not yet been referenced specifically in any publications.

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Thank you for contacting us. I have had an opportunity to go through a number of our antibodies and discuss your needs with the laboratory. Unfortunately, the difference in homology between these Xenopus targets and the peptides from which each immun...

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