Anti-FOXH1 antibody - N-terminal (ab189960)

Overview

  • Product name
    Anti-FOXH1 antibody - N-terminal
    See all FOXH1 primary antibodies
  • Description
    Rabbit polyclonal to FOXH1 - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human FOXH1 (N terminal). The peptide corresponds to 19 amino acids.
    Database link: O75593

  • Positive control
    • Human prostate and liver tissue. Human liver lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab189960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 39 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function
    Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Contains 1 fork-head DNA-binding domain.
  • Domain
    The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated SMAD2 that is in an activated SMAD complex.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • FAST 1 antibody
    • Fast 2 antibody
    • Fast-1 antibody
    • Fast-2 antibody
    • FAST1 antibody
    • Fast2 antibody
    • Forkhead activin signal transducer 1 antibody
    • Forkhead activin signal transducer 2 antibody
    • Forkhead box H1 antibody
    • Forkhead box protein H1 antibody
    • FOX H1 antibody
    • FOXH 1 antibody
    • FOXH1 antibody
    • FOXH1_HUMAN antibody
    • hFAST 1 antibody
    • hFAST-1 antibody
    • hFAST1 antibody
    • Human homolog of Xenopus forkhead activin signal transducer 1 antibody
    • TGF beta/Activin signal transducer FAST1 antibody
    see all

Images

  • Anti-FOXH1 antibody - N-terminal (ab189960) at 1 µg/ml + human liver tissue lysate

    Predicted band size: 39 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human prostate tissue labeling FOXH1 with ab189960 at 5 µg/ml.

  • Immunofluorescence analysis of human liver tissue labeling FOXH1 with ab189960 at 20 µg/ml.

References

ab189960 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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