Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab57216 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1 - 5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionTranscriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development.
    • Involvement in diseaseNote=A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.
      Defects in FOXP1 are the cause of mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670]. It is a developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors.
    • Sequence similaritiesContains 1 C2H2-type zinc finger.
      Contains 1 fork-head DNA-binding domain.
    • DomainThe leucine-zipper is required for dimerization and transcriptional repression.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 12CC4 antibody
      • FLJ23741 antibody
      • Fork head related protein like B antibody
      • Forkhead box P1 antibody
      • Forkhead box protein P1 antibody
      • FOX P1 antibody
      • FOXP 1 antibody
      • foxp1 antibody
      • FOXP1_HUMAN antibody
      • Glutamine rich factor 1 antibody
      • hFKH1B antibody
      • HSPC215 antibody
      • MGC12942 antibody
      • MGC88572 antibody
      • MGC99551 antibody
      • QRF 1 antibody
      • QRF1 antibody
      see all

    Anti-FOXP1 antibody images

    References for Anti-FOXP1 antibody (ab57216)

    ab57216 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"